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Recombinant Human IFN-alpha/beta R1 Protein(aa 28-436), His

Cat NoBIOP3623
Conjugate
Type药物靶点
SourceHEK293
TagHis
Size10 ug
ApplicationImmunogen
FormatLyophilized
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in 20mM PB, 150mM NaCl, pH 7.2.
SpeciesHuman
StorageStore at –20 degree. Avoid repeated freeze/thaw cycles.
SynonymsInterferon Alpha/Beta Receptor 1;IFN-R-1;IFN-Alpha/Beta Receptor 1;Cytokine Receptor Class-IIMember 1;Cytokine Receptor Family 2 Member 1;CRF2-1;Type I Interferon Receptor 1;IFNAR1;IFNAR
Purification> 95% by SDS-PAGE.
MolecularWeight
Descriptionaa 28-436
BackgroundThe Interferon-α/β Receptor 1 (IFN-α/β R1) is a receptor which binds Type I Interferons including Interferon-αand - β . It is a cell surface receptor and heteromeric receptor composed of one chain with two subunitsreferred to as IFNAR1 and IFNAR2. IFN- α / β R1, in association with IFN- α / β R2, is required for propagatingantiviral signal transduction triggered by IFN- α and IFN- β . IFN- α / β R1 interacts very weakly or not at all withtype 1 interferons and does not stably interact with IFN- α / β R2. Ligands associate with IFN- α / β R2, and thiscomplex subsequently forms a stable ternary assembly with IFN-α/β R1. IFN-α/β R1 also associates with IFN-γR2 even in the absence of IFN- γ stimulation. Human IFN- α / β R1 contains a nuclear localization signal in itsextracellular domain that is required for receptor translocation to the nucleus following interaction withligand. Interferon stimulation results in an immunologic response that is especially associated with viruses.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.
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