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Recombinant Human CD46 Protein(aa 35-328), His

Cat NoBIOP2886
Conjugate
Type生物标志物
SourceHEK293
TagHis
Size10 ug
ApplicationImmunogen
FormatLyophilized
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS, pH 7.4.
SpeciesHuman
StorageStore at –20 degree. Avoid repeated freeze/thaw cycles.
SynonymsAHUS2;MCP;MIC10;TLX;TRA2.10
Purification> 90% by SDS-PAGE.
MolecularWeight
Descriptionaa 35-328
BackgroundThe recombinant human CD46 consists of 305 amino acids with a molecular weight of 34 kDa. The apparent molecular mass of recombinant human CD46 is about 55-60 kDa in SDS-PAGE under reducing conditions due to glycosylation.CD46 is also known as MCP and is a type I membrane protein that functions as a cofactor for Complement Factor I-mediated inactivation of complement components C3b and C4b. CD46 is expressed in white blood cells, platelets, epithelial cells, and fibroblasts. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2),a disease characterized by uncontrolled complement activation.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.
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