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Mouse Anti-Mouse Foxp3 Antibody(Clone 3G3), FITC

Cat NoBIOS-2637F
Conjugate
Type流式抗体
Clone3G3
SourceMouse
TagFITC
Size1 mg
ApplicationFCM
ApplicationNoteEach lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 碌L of antibody per test (million cells in 100 碌L staining volume or per 100 碌L of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
FormatLiquid
Purity>90%
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS; pH 7.4.
StorageStore at -20 degree for long term.
SynonymsForkhead box protein P3;IPEX;JM2;Foxp3
PurificationSDS-PAGE
MolecularWeight
Description
BackgroundFOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25-聽cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in 'scurfy' mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 未2) lacking exon 2.
We can provide a variety of products such as diagnostic proteins; target proteins; cytokines; etc.
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