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Rat Anti-Mouse CD8a Antibody(Clone 53-6.7), APC

Cat NoBIOS-1693F
Conjugate
Type流式抗体
Clone53-6.7
SourceRat
TagAPC
Size1 mg
ApplicationFCM
ApplicationNoteEach lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 μL of antibody per test (million cells in 100 μL staining volume or per 100 μL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
FormatLiquid
Purity>90%
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS; pH 7.4.
StorageStore at -20 degree for long term.
SynonymsT-cell surface glycoprotein CD8 alpha chain;CD8A;T-lymphocyte differentiation antigenT8/Leu-2;MAL
PurificationSDS-PAGE
MolecularWeight
Description
BackgroundCD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.
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