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Rat Anti-Mouse CD279/PD-1 Antibody(Clone 29F.1A12), PE/Cyanine7

Cat NoBIOS-1407F
Conjugate
Type流式抗体
Clone29F.1A12
SourceRat
TagPE/Cyanine7
Size1 mg
ApplicationFCM
ApplicationNoteEach lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results (Clone The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume).
FormatLiquid
Purity>90%
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS; pH 7.4.
StorageStore at -20 degree for long term.
SynonymsPDCD1;PD1;Protein PD-1;hPD-1
PurificationSDS-PAGE
MolecularWeight
Description
BackgroundProgrammed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 and PD-L2 are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.
We can provide a variety of products such as diagnostic proteins; target proteins; cytokines; etc.
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