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Mouse Anti-Human CD274/PD-L1 Antibody(Clone 29E.2A3), AF/LE Purified

Cat NoBIOS-1390F
Conjugate
Type流式抗体
Clone29E.2A3
SourceMouse
TagAF/LE Purified
Size1 mg
ApplicationFCM
ApplicationNoteEach lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 μg per 106 cells in 100 μL volume or 100 μL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
FormatLiquid
Purity>90%
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS; pH 7.4.
StorageStore at -20 degree for long term.
SynonymsB7-H1;PD-L1;Programmed cell death ligand 1;B7 homolog 1;B7-H;B7H1;PDL1;PDCD1L1;PDCD1LG1
PurificationSDS-PAGE
MolecularWeight
Description
BackgroundCD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.
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