中文English Call: 400-669-8850 | E-mail: info@biotyscience.com

流式抗体

当前位置:首页 >>产品中心 >>抗体产品 >>一抗 >>流式抗体

Contact us

Biotyscience Inc

Tel 400-669-8850

E-mail info@biotyscience.com

QQ  499854788

       82458988


Rat Anti-Mouse CD272 Antibody(Clone PK18.6), PE

Cat NoBIOS-1357F
Conjugate
Type流式抗体
ClonePK18.6
SourceRat
TagPE
Size1 mg
ApplicationFCM
ApplicationNoteEach lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 μL of antibody per test (million cells in 100 μL staining volume or per 100 μL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
FormatLiquid
Purity>90%
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS; pH 7.4.
StorageStore at -20 degree for long term.
SynonymsB- and T-lymphocyte attenuator;Btla;B- and T-lymphocyte-associated protein;CD272;Btla
PurificationSDS-PAGE
MolecularWeight
Description
BackgroundCD272, also known as B and T lymphocyte attenuator (BTLA), is an Ig superfamily co-inhitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand herpes virus entry mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significantly higher expression of BTLA compared with effectors and na?ve T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It was reported that BTLA may regulate T cell function by binding to B7-H4, but further studies are needed to confirm. The existence of three distinct BTLA alleles has been reported.
We can provide a variety of products such as diagnostic proteins; target proteins; cytokines; etc.
客服:
400-669-8850
产品:
177-3110-0244
服务:
136-8125-6816
QQ 在线咨询

微信二维码
电子邮箱
info@biotyscience.com