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Cat No | BIOC1218 |
Conjugate | |
Type | Carrier Material |
Source | N/A |
Size | 1 g |
Application | |
Format | Powder |
Buffer | CHCl3、DCM |
Storage | Store at -20℃. Keep away from light. |
Synonyms | 聚己内酯-聚乙二醇-羧基;PCL-PEG-COOH;pcl cooh |
Purification | ≥95% |
MolecularWeight | 2000/3400/5000 |
Description | |
Background | Poly(ε-caprolactone)-block-poly(ethylene glycol)-carboxylic acid (PCL-PEG-COOH) is a functional amphiphilic block copolymer (ABC) which has carboxylic group at the end of PEG block and is used to prepare nanoparticles and micelles for targeted drug delivery. PCL-PEG is one of the most commonly used biodegradable ABC polymers for drug delivery. PCL-PEG-COOH is an amphiphile polymer with hydrophobic polycaprolactone (PCL) and hydrophilic PEG. The self-assembling polymer forms micelles which can be used to entrap hydrophobic drugs. The terminal carboxyl can react with amine in the presence of HATU or EDC to form a stable amide bond. |