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Cat No | BIOC1143 |
Conjugate | |
Type | Carrier Material |
Source | N/A |
Size | 1 g |
Application | |
Format | Powder |
Storage | Store at 2-8℃. Keep away from light. |
Synonyms | HO-PEG-Mal;羟基-聚乙二醇-马来酰亚胺 |
Purification | ≥95% |
MolecularWeight | 2000/3400/5000 |
Description | |
Background | HO-PEG-Mal, MW 2,000 is a thiol reactive PEG polymer. The PEG is water soluble and hydroxyl moiety allows further modification with other reactive group.HO-PEG-mal (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |