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Rabbit Anti-Cytokeratin 14 Monoclonal Antibody (Fluor 594), clone SA-010

Cat NoBSMA-0058
Conjugate
TypeRecombinant Rabbit Monoclonal Antibody
SourceRabbit
TagFluor 594
Size100 ug
ApplicationIF
FormatLiquid
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in 0. 02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68. 98% PBS.
StorageStore at -20 degree. Avoid repeated freeze/thaw cycles.
SynonymsCK 14;CK-14;ck14;Cytokeratin 14;Cytokeratin-14;Cytokeratin14;Dowling Meara;EBS3;EBS4;Epidermolysis bullosa simplex;K14;K1C14_HUMAN;Keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner);Keratin 14;Keratin;Keratin type I cytoskeletal 14;Keratin, type I cytoskeletal 14;Keratin-14;Keratin14;Koebner;Krt 14;Krt14;NFJ;OTTHUMP00000164624;type I cytoskeletal 14
PurificationProtein A affinity purified.
NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MolecularWeight52 kDa
Description
BackgroundCytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed in pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The a-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins are useful markers of tissue differentiation and, in addition, they aid in the characterization of malignant tumors. In Bowen’s disease, the characteristic malignancy of the epidermis exhibits distinct expression patterns of Cytokeratin 14. The gene encoding human Cytokeratin 14 maps to chromosome 17q12-21. Mutations in this gene lead to epidermolysis bullosa simplex, an inheritied skin disorder characterized by skin blistering due to basal keratinocyte fragility.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.
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