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Rabbit Anti-Cadherin 5 Polyclonal Antibody

Cat NoBSPA-1421
Conjugate
TypePolyclonal Antibody
SourceRabbit
Size1 mg
ApplicationWB; IHC-P; ELISA
FormatLiquid
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS.
StorageStore at -20 degree. Avoid repeted freeze/thaw cycl.
SynonymsCDH5;Cadherin-5;7B4 antigen;Vascular endothelial cadherin;VE-cadherin;CD antigen CD144
Purification
NoteTis product l is eeze eezeleezeegrrch useeze ly, no useeze huma, apeut agnost apcal.
MolecularWeight
Description
BackgroundCadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. They play important roles
in cell adhesion, ensuring that cells within tissues are bound together. They are dependent on calcium(Ca2+) ions to
function. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-
spanning domain, and a small highly conserved C-terminal cytoplasmic domain. Type Il (atypical) cadherins are defined
based on their lack of an HAV cell adhesion recognition sequence specific to type I cadherins. It has been observed that
cells containing a specific cadherin subtype tend to cluster together to the exclusion of other types, both in cell culture
and during development. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, is single-pass type I membrane
protein. It is expressed in endothelial tissues and brain and is involved in loss of heterozygosity events in breast and
prostate cancer. CDH5 is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin
repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by
imparting to cells the ability to adhere in a homophilic manner, CDH5 may play an important role in endothelial cell
biology through control of the cohesion and organization of the intercellular junctions.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.
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