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Cat No | BSA-0072A |
Conjugate | |
Type | 重组蛋白 |
Source | Mammalian cell |
Tag | His |
Size | 1 mg |
Application | Immunogen; Calibrator; Standard |
Format | Liquid |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in 1×PBS, pH 7. 4. |
Storage | Store at -20 degree. Avoid repeated freeze/thaw cycles. |
Synonyms | 酪氨酸蛋白激酶受体;AXL;Axl;Ark;Ufo;Tyro-7 |
Purification | > 90% by SDS-PAGE |
Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
MolecularWeight | |
Description | |
Background | 酪氨酸蛋白激酶受体(Axl)又名Ark、Ufo和Tyro-7, 是一种细胞表面的跨膜受体, Axl的相对分子量约为140KD. 由分布在44kb区城的20个外显子编码, 基因位于第19号染色体. 分子分为胞外区、胞内区和跨脯区3部分:其中胞外区包括2个免疫球蛋白样区(lg)和2个纤连蛋白Ⅲ(FNⅢ)样区. Ig样区是配体结合区, FNⅢ区在AxJ与配体结合的过程中起调节作用. Axl的胞外区与神经细胞贴附分子结构相似; 且胞内区有酪氨酸激醇活性, 所以Axl可促进细胞粘附和增殖. Axl与配体生长停滞特异性基因6(Gas6)蛋白结合, 发生磷酸化, 磷酸化位点与相应蛋白结合, 激活下游信号转导通路, 进而发挥促进细胞增殖、抗凋亡、迁移、侵袭等生物学功能. |