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Cat No | BIOP2925 |
Conjugate | |
Type | 生物标志物 |
Source | HEK293 |
Tag | His |
Size | 10 ug |
Application | Immunogen |
Format | Lyophilized |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in PBS, pH 7.4. |
Species | Human |
Storage | Store at –20 degree. Avoid repeated freeze/thaw cycles. |
Synonyms | Natural killer cells antigen CD94;KP43;Killer cell lectin-like receptor subfamily D member 1;NKcell receptor;CD94;KLRD1 |
Purification | > 95% by SDS-PAGE. |
MolecularWeight | |
Description | aa 34-179 |
Background | CD94 (Cluster of Differentiation 94), also known as killer cell lectin-like receptor subfamily D member 1(KLRD1), is expressed on the surface of natural killer cells in the innate immune system. CD94 Plays a role as areceptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. CD94 Canform disulfide-bonded heterodimer with NKG2 family members. The CD94/NKG2 complex, on the surface ofnatural killer cells interacts with Human Leukocyte Antigen (HLA)-E on target cells. Natural killer (NK) cells are adistinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immunestimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, areexpressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigenpreferentially expressed on NK cells and is classified as a type II membrane protein because it has an external Cterminus. |