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Cat No | BIOP2913 |
Conjugate | |
Type | 生物标志物 |
Source | HEK293 |
Tag | His |
Size | 10 ug |
Application | Immunogen |
Format | Lyophilized |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in PBS, pH 7.4. |
Species | Human |
Storage | Store at –20 degree. Avoid repeated freeze/thaw cycles. |
Synonyms | Interleukin-13 receptor subunit alpha-1;IL-13 receptor subunit alpha-1;IL-13R subunit alpha-1;IL-13R-alpha-1;IL-13RA1;Cancer/testis antigen 19;CT19;CD213a1;IL13RA1;IL13R;IL13RA |
Purification | > 95% by SDS-PAGE. |
MolecularWeight | |
Description | aa 22-343 |
Background | Interleukin-13 receptor subunit alpha-1(IL13RA1) is a subunit of the interleukin 13 receptor. This subunit formsa receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. The human IL13-R α1was originally cloned based on sequence homology to the mouse IL13-Rα1, it share 76% aa sequence identity.Human The IL13-R α 1 cDNA encodes a 427 amino acid (aa) residue precursor protein with a putative 21 aaresidue signal peptide, a 324 aa residue extracellular domain, a 23 aa residue transmembrane region and a 59aa residue cytoplasmic tail. The extracellular domain of IL13-Rα 1 is also closely related to that of IL13-Rα 2. Itbinds with low affinity to interleukin-13(IL13). IL13RA1 serves as a primary IL13- binding subunit of the IL13receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinaseTYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6induced by IL13 and IL4. |