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Cat No | BIOP2870 |
Conjugate | |
Type | 生物标志物 |
Source | HEK293 |
Tag | His |
Size | 50 ug |
Application | Immunogen |
Format | Lyophilized |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in PBS Buffer, pH 7.4. |
Species | Human |
Storage | Store at –20 degree. Avoid repeated freeze/thaw cycles. |
Synonyms | CD221;IGF-I R;IGF1 Receptor;IGFIR;IGFR;JTK13;IGF1R |
Purification | > 90 % by SDS-PAGE. |
MolecularWeight | |
Description | aa 1-932 |
Background | This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |