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Cat No | BIOP2609 |
Conjugate | |
Type | 其他蛋白 |
Source | HEK293 |
Tag | His |
Size | 20 ug |
Application | Immunogen |
Format | Lyophilized |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in PBS, pH 7.4. |
Species | Human |
Storage | Store at –20 degree. Avoid repeated freeze/thaw cycles. |
Synonyms | Semaphorin-3G;Semaphorin sem2;SEMA3G |
Purification | > 90% by SDS-PAGE. |
MolecularWeight | |
Description | |
Background | Semaphorin 3G (Sema3G), also known as Semaphorin sem2, is a class 3 member of the semaphorin family initially identified as regulators of neuron-axonal guidance. More than 30 semaphorins have been discovered and are divided into eight classes: classes 1 and 4-7 are membrane-associated, while classes 2, 3, and 8 are in a secreted form. In vitro analysis shows Sema 3G binds to Neuropilin-2, which forms a receptor complex with Plexin-D1. Via this pathways Sema 3G controls lymphatic vascular patterning by the means of cellular collapse. It shows protective effects in ischemic retinopathies by coordinating interactions of beta -catenin and VE-Cadherin in endothelium. Sema 3G has been shown to be involved in adipocyte differentiation. Knockdown of Sema3G inhibited weight gain through PI3K/Akt/GSK3 beta signaling in the adipose tissue and the AMPK/SREBP-1c pathway in the liver. Thus, Sema 3G is an adipokine essential for adipogenesis, lipogenesis, and insulin resistance and is associated with obesity. |