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Cat No | BIOP2582 |
Conjugate | |
Type | 其他蛋白 |
Source | E. coli |
Tag | His |
Size | 10 ug |
Application | Immunogen |
Format | Lyophilized |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in 20mM PB, 150mM NaCl, pH 7.2 |
Species | Human |
Storage | Store at –20 degree. Avoid repeated freeze/thaw cycles. |
Synonyms | Estrogen Receptor;ER;ER-Alpha;Estradiol Receptor;Nuclear Receptor Subfamily 3 Group A Member 1;ESR1;ESR;NR3A1 |
Purification | > 95% by SDS-PAGE. |
MolecularWeight | |
Description | aa 1-116 |
Background | Estrogen Receptor is a major ligand--‐activated transcription factor belonging to the nuclear hormone receptor superfamily. Estrogen Receptor is composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but they also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5 UTRs and use different promoters. |