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Cat No | BIOP2477 |
Conjugate | |
Type | 其他蛋白 |
Source | E. coli |
Tag | His |
Size | 10 ug |
Application | Immunogen |
Format | Lyophilized |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in 20mM HEPES, 150mM NaCl, 10mM β-ME, pH 7.4. |
Species | Human |
Storage | Store at –20 degree. Avoid repeated freeze/thaw cycles. |
Synonyms | HH13;HH7-2;HU-PP-1;OV-1;PRL-2;PRL2;PTP4A;PTPCAAX2;ptp-IV1a;ptp-IV1b |
Purification | > 95% by SDS-PAGE. |
MolecularWeight | |
Description | aa 1-167 |
Background | PTP4A2, also known as PRL2 or PTPCAAX2, is short for Protein tyrosine phosphatase type IVA 2. This protein exists in cell membrane, cytoplasm,endosome and membrane. PTP4A2 is often farnesylated during post-translational modification. Farnesylation is required for membrane targeting and for interaction with RABGGTB. The unfarnesylated forms are redirected to the nucleus and cytosol. It can stimulate progression from G1 into S phase during mitosis and promotes tumors. It also inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. |