Biotyscience Inc
Tel 400-669-8850
E-mail info@biotyscience.com
QQ 499854788
82458988
Cat No | BIOP2417 |
Conjugate | |
Type | 其他蛋白 |
Source | E. coli |
Tag | His |
Size | 50 ug |
Application | Immunogen |
Format | Liquid |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in 50mM HEPES,200mM NaCl,10%glycerol,1mM TCEP,pH 7.0 |
Species | Human |
Storage | Store at –20 degree. Avoid repeated freeze/thaw cycles. |
Synonyms | E2-F1;L-UBC;UBCH7;UbcM4 |
Purification | > 95% by SDS-PAGE. |
MolecularWeight | |
Description | aa 1-154 |
Background | Ubiquitin-conjugating Enzyme E2L 3 (UBE2L3),also known as Ubiquitin-conjugating Enzyme H7 (UbcH7), is a member of the Ubiquitin-conjugating (E2) enzyme family (1). The human UbcH7 protein shares 100% amino acid (aa) sequence identity with the mouse and rat orthologs. UBE2L3 is catalytically active with HECT and RBR domain-containing families of Ubiquitin ligases (E3s). UBE2L3 localizes to both the nucleus and cytoplasm in human cells. UBE2L3 depletion results in an extended S phase and a reduced rate of proliferation, suggesting that it may play a role in the cell cycle. In humans, single nucleotide polymorphisms in UBE2L3 are associated with systemic lupus erythematosus and Crohns disease, suggesting that UbcH7 is important for proper immune system function. |