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Recombinant Human UBE2L3 Protein(aa 1-154), His

Cat NoBIOP2417
Conjugate
Type其他蛋白
SourceE. coli
TagHis
Size50 ug
ApplicationImmunogen
FormatLiquid
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in 50mM HEPES,200mM NaCl,10%glycerol,1mM TCEP,pH 7.0
SpeciesHuman
StorageStore at –20 degree. Avoid repeated freeze/thaw cycles.
SynonymsE2-F1;L-UBC;UBCH7;UbcM4
Purification> 95% by SDS-PAGE.
MolecularWeight
Descriptionaa 1-154
BackgroundUbiquitin-conjugating Enzyme E2L 3 (UBE2L3),also known as Ubiquitin-conjugating Enzyme H7 (UbcH7), is a member of the Ubiquitin-conjugating (E2) enzyme family (1). The human UbcH7 protein shares 100% amino acid (aa) sequence identity with the mouse and rat orthologs. UBE2L3 is catalytically active with HECT and RBR domain-containing families of Ubiquitin ligases (E3s). UBE2L3 localizes to both the nucleus and cytoplasm in human cells. UBE2L3 depletion results in an extended S phase and a reduced rate of proliferation, suggesting that it may play a role in the cell cycle. In humans, single nucleotide polymorphisms in UBE2L3 are associated with systemic lupus erythematosus and Crohns disease, suggesting that UbcH7 is important for proper immune system function.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.
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