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Cat No | BIOP2112 |
Conjugate | |
Type | 白介素 |
Source | HEK293 |
Size | 10 ug |
Application | Immunogen |
Format | Lyophilized |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in PBS, pH 7.4. |
Species | Mouse |
Storage | Store at –20 degree. Avoid repeated freeze/thaw cycles. |
Synonyms | SGRF;IL-23p19;CLMF p40;IL-12 subunit p40;NKSF2 |
Purification | > 95% by SDS-PAGE. |
MolecularWeight | |
Description | aa 22-196 |
Background | Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit thatis unique to IL-23, and a p40 subunit that is shared with IL-12. The p19 subunit has homology to the p35subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologousto the extracellular domains of the hematopoietic cytokine receptors. Although p19 is expressed by activatedmacrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cellsexpress p40 concurrently to produce IL-23. IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts onboth naive and memory human T cells, the effects of IL-23 is restricted to memory T cells. |