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Recombinant Human HER2/ErbB2 Protein(aa 23-652), His

Cat NoBIOP1812
Conjugate
TypeCAR-T相关
SourceHEK293
TagHis
Size10 ug
Application

Immunogen

FormatLyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
ConcentrationPlease refer to the vial lable for the specific concentration.
SpeciesHuman
StorageStore at –20 degree. Avoid repeated freeze/thaw cycles. After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
SynonymsCD340;HER-2;HER-2/neu;HER2;MLN 19;MLN19;NEU;NGL;TKR1
Purification> 95% by SDS-PAGE.
MolecularWeight
Descriptionaa 23-652
BackgroundEpidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. ErbB2 has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.

We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.

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