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Cat No | ADMD-162 |
Conjugate | |
Type | 重组蛋白 |
Source | E. coli |
Size | 1mg |
Application | Immunology |
Format | Liquid |
Purity | ≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined bySEC-HPLC. |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in PBS |
Species | Human |
Storage | Store at -20 degree. Avoid repeated freeze/thaw cycles. |
Synonyms | Epidermal Growth Factor Protein, Human;HOMG4 Protein, Human;URG Protein, Human |
Purification | |
Note | For research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. |
MolecularWeight | |
Description | |
Background | EGF is the founding member of the EGF-family of proteins. Membersofthis protein family have highly similar structural andfunctionalcharacteristics. EGF contains 9 EGF-like domains and9LDL-receptorclass B repeats. Human EGF is a 6045-Da protein with53aminoacidresidues and three intramolecular disulfide bonds. As alow-molecular-weight polypeptide, EGF was first purified fromthe mousesubmandibulargland, but since then it was found in many human tissuesincludingsubmandibular gland, parotid gland. It can also be foundinhumanplatelets, macrophages, urine, saliva, milk, and plasma. EGFisagrowthfactor that stimulates the growth of various epidermal andepithelialtissues in vivo and in vitro and of some fibroblasts in cell culture. It resultsin cellular proliferation, differentiation, and survival. SalivaryEGF, whichseems also regulated by dietary inorganic iodine, also playsanimportantphysiological role in the maintenance of oro-esophageal andgastrictissue integrity. EGF acts by binding with high affinity to epidermal growthfactor receptor on the cell surface and stimulating the intrinsicproteintyrosine kinase activity of the receptor. The tyrosine kinaseactivity, inturn,initiates a signal transduction cascade that results inavarietyofbiochemical changes within the cell - a rise in intracellular calciumlevels,increased glycolysis and protein synthesis, and increasesintheexpression of certain genes including the gene for EGFR- that ultimatelylead to DNA synthesis and cell proliferation. |