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Rabbit Anti-Cadherin 5 Polyclonal Antibody

Cat NoBSPA-1421
Conjugate
TypePolyclonal Antibody
SourceRabbit
Size1 mg
ApplicationWB; IHC-P; ELISA
FormatLiquid
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS.
StorageStore at -20 degree. Avoid repeted freeze/thaw cycl.
SynonymsCDH5;Cadherin-5;7B4 antigen;Vascular endothelial cadherin;VE-cadherin;CD antigen CD144
Purification
NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MolecularWeight
Description
BackgroundCadherins are a class of transmembrane proteins. They play important roles
in cell adhesion, ensuring that cells within tissues are bound together. They are dependent on calcium ions to
function. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-
spanning domain, and a small highly conserved C-terminal cytoplasmic domain. Type Il cadherins are defined
based on their lack of an HAV cell adhesion recognition sequence specific to type I cadherins. It has been observed that
cells containing a specific cadherin subtype tend to cluster together to the exclusion of other types, both in cell culture
and during development. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, is single-pass type I membrane
protein. It is expressed in endothelial tissues and brain and is involved in loss of heterozygosity events in breast and
prostate cancer. CDH5 is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin
repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by
imparting to cells the ability to adhere in a homophilic manner, CDH5 may play an important role in endothelial cell
biology through control of the cohesion and organization of the intercellular junctions.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.
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