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Rabbit Anti-ATG2A Polyclonal Antibody

Cat NoBSPA-1083
Conjugate
TypePolyclonal Antibody
SourceRabbit
Size1 mg
ApplicationELISA; IHC
FormatLiquid
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS.
SpeciesHuman
StorageStore at -20 degree. Avoid repeted freeze/thaw cycl.
SynonymsATG2A;autophagy related 2A
Purification
NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MolecularWeight
Description
BackgroundAtg2A is a 1,938 amino acid protein that belongs to the ATG2 family and may play a role in vesicle assembly. Encoded by a gene that maps to human chromosome 11q13.1, Atg2A is conserved in chimpanzee, dog, cow, mouse and rat, and exists as four alternatively spliced isoforms. Undetected in adult tissues, including heart, brain, placenta, lung, liver and skeletal muscle, Atg2A regulation may act as a distinct indicator of autophagic programmed cell death. Atg2A is upregulated in both etoposide- and doxorubicin-induced apoptosis of HeLa cells, suggesting that Atg2A functions as a novel biomarker of topoisomerase II inhibitor-mediated apoptosis. Atg2A associates with Atg2B, indicating that these two related proteins also functionally interact. Atg2A frameshift mutations are linked to gastric and colorectal carcinomas with high microsatellite instability and may contribute to cancer development by deregulating the autophagy process. Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.
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