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Cat No | BPA-15764 |
Conjugate | |
Type | 多克隆抗体 |
Source | Rabbit |
Tag | N/A |
Size | 50 ul |
Application | ELISA; IHC-P; IHC-F; IF |
Format | Liquid |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Storage | Store at –20 degree. Avoid repeated freeze/thaw cycles. |
Synonyms | AF1Q;ALL1 fused gene from chromosome 1q;MLLT 11;MLLT-11;Myeloid/lymphoid or mixed lineage leukemia (trithorax homolog, Drosophila) translocated to 11;Protein AF1q;RP11 316M1.10;AF1Q_HUMAN. |
Purification | Protein A |
MolecularWeight | |
Description | |
Background | The gene encoding the Mixed-Lineage Leukemia (MLL) proteins is located on chromosome 11q23. Chromosomal translocations involving band 11q23 result in rogue activator proteins that are associated with approximately 10% of patients with acute lymphoblastic leukemia (ALL) and 5% of patients with acute myeloid leukemia (AML). Most patients affected are less than 1 year of age. MLLT11, also known as mixed-lineage leukemia translocated to 11 or AF1q, is a 90 amino acid MLL fusion partner. Based on the expression patterns of MLLT11, it is thought that MLLT11 plays a role in leukemogenesis and, specifically, the progression of acute monocytic leukemia (AML). Also, expressed in embryonic brain cortex, MLLT11 is upregulated during neuronal differentiation and is thought to play a role in the development of the central nervous system. Finally, MLLT11 has been shown to be differentially expressed in highly metastatic cells, in comparison with non-metastatic parent cells. Such findings suggest a role of MLLT11 in tumorigenesis. |