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Cat No | BSPA-0993 |
Conjugate | |
Type | Polyclonal Antibody |
Source | Rabbit |
Size | 1 mg |
Application | ELISA; IHC |
Format | Liquid |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in PBS. |
Species | Human |
Storage | Store at -20 degree. Avoid repeted freeze/thaw cycl. |
Synonyms | ARIH1;ariadne RBR E3 ubiquitin protein ligase 1;ARI;HARI;HHARI;UBCH7BP |
Purification | |
Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
MolecularWeight | |
Description | |
Background | ARIH1 , also known as ubiquitin conjugating enzyme E2 binding protein 1, ARI, HARI, HHARI , MOP-6 or UBCH7BP , is a 557 amino acid cytoplasmic protein. Expressed in a wide variety of tissues, ARIH1 contains two RING-type zinc fingers and one IBR -type domain. ARIH1 is believed to be involved in protein degradation and protein translation. ARIH1 interacts with UBCH7 and is thought to function as an E3 ubiquitin-protein ligase that, characteristic of E3 ligase proteins, accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and transfers that ubiquitin residue to substrates targeted for degradation. Specifically, ARIH1 interacts with and polyubiquitylates eIF4E2, thereby targeting it for proteasomal degradation. |