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Cat No | BSMA-4329-D |
Conjugate | |
Type | 单克隆抗体 |
Clone | C13744 |
Source | Mouse |
Tag | N/A |
Size | 1 mg |
Application | LFIA; CLIA |
Format | Liquid |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in 1×PBS, pH 7. 4. |
Storage | Store at -20 degree. Avoid repeated freeze/thaw cycles. |
Synonyms | 抑制素A;InhibinA;INHA |
Purification | > 95% |
Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
MolecularWeight | |
Description | |
Background | 抑制素A(InhibinA, INHA)是一种由成熟卵泡和黄体分泌的糖蛋白激素, 由a和A亚基经二硫键连接而成. 抑制素A是妊娠期间具有生物活性的主要抑制素, 表达量随妊娠进展而升高, 在足月时达高峰. 抑制素A对维持妊娠发生、发展、胎儿生长发育有重要作用. 它能够抑制垂体性腺激素合成、分泌, 通过竟争性结合激活素A受体Ⅱ, 阻止激活素A与激活素A受体Ⅱ的结合, 抑制激活素A生物活性. 此外抑制素A还可以刺激母体、胎儿促肾上腺皮质激素(ACTH)和生长激素(GH)的释放, 促进红细胞生成. 抑制素A(Inhibin A)临床上主要用于唐氏筛查及其他妊娠期疾病的检测和诊断. 它与AFP、ShCG、fE3联合检测可以降低唐氏综合征筛查的假阳, 提高检出率. |