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Mouse Anti-GFAP Monoclonal Antibody (Fluor 488), clone SA-004

Cat NoBSMA-0052
Conjugate
TypeMonoclonal Antibody
SourceMouse
TagFluor 488
Size100 ug
ApplicationIF
FormatLiquid
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in 0. 02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68. 98% PBS.
StorageStore at -20 degree. Avoid repeated freeze/thaw cycles.
Synonymsfb34h11;ALXDRD;cb345;etID36982. 3;FLJ42474;FLJ45472;GFAP;GFAP_HUMAN;gfapl;Glial fibrillary acidic protein;Intermediate filament protein;wu: fk42c12;xx: af506734;zgc: 110485
PurificationProtein G affinity purified.
NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MolecularWeight50 kDa
Description
BackgroundGlial fibrillary acidic protein (GFAP) is an intermediate filament protein. The protein is the smallest (8 nm) of the intermediate filament proteins with a molecular weight of about 51 kDa. In the central nervous system, GFAP is expressed in astrocytes and ependymal cells but not in other glial cells. However, immature oligodendrocytes and immature choroid plexus cells may be GFAP positive. In the peripheral nervous system enteric Schwann cells and satellite cells of human sensory ganglia express GFAP. Outside the nervous system, GFAP is seen in myoepithelial cells and chondroblasts, in the former coexpressed with cytokeratin, in the latter coexpressed with vimentin. Astrocytoma, ependymoma, glioblastoma, and oligodendroglioma are almost always positive. Plexus carcinoma, ganglioglioma and primitive neuroectodermal tumours (PNET: neuroblastoma a.o.) express GFAP to a varying extent. Schwannoma and neurofibroma frequently express GFAP. Chondroma, chondrosarcoma and pleomorphic adenoma are also GFAP positive in most cases. A few carcinomas (especially from lung and breast) may express GFAP. in paraganglioma GFAP may be detected in sustentacular cells.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.
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