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Cat No | BMA-2499 |
Conjugate | |
Type | Monoclonal Antibody |
Source | Mouse |
Size | 0.1 ml |
Application | WB; ELISA; IHC-P; FCM |
Format | Liquid |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in PBS with 0.05% sodium azide. |
Storage | Store at –20 degree. Avoid repeated freeze/thaw cycles. |
Synonyms | Probable ATP-dependent RNA helicase DDX5;DEAD box protein 5;RNA helicase p68;G17P1;HELR;HLR1;HUMP68. |
Purification | |
MolecularWeight | 69.1 kDa |
Description | |
Background | Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. |