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Mouse Anti-DDX5 Monoclonal Antibody

Cat NoBMA-2499
Conjugate
TypeMonoclonal Antibody
SourceMouse
Size0.1 ml
ApplicationWB; ELISA; IHC-P; FCM
FormatLiquid
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS with 0.05% sodium azide.
StorageStore at –20 degree. Avoid repeated freeze/thaw cycles.
SynonymsProbable ATP-dependent RNA helicase DDX5;DEAD box protein 5;RNA helicase p68;G17P1;HELR;HLR1;HUMP68.
Purification
MolecularWeight69.1 kDa
Description
BackgroundInvolved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation.
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