中文English Call: 400-669-8850 | E-mail: info@biotyscience.com

单克隆抗体

当前位置:首页 >>产品中心 >>抗体产品 >>一抗 >>单克隆抗体

Content

Contact us

Biotyscience Inc

Tel 400-669-8850

E-mail info@biotyscience.com

QQ  499854788

       82458988


Rabbit anti-Human NCF4/p40-phox Monoclonal Antibody

Cat NoBMA-2254
Conjugate
Type重组兔多抗
SourceRabbit
Size50 uL
ApplicationImmunogen
FormatLiquid
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
SpeciesHuman
StorageStore at -20℃. Avoid freeze / thaw cycles.
SynonymsNCF4;CGD3;NCF;P40PHOX;SH3PXD4;neutrophil cytosol factor 4
PurificationAffinity purification
MolecularWeight40KDa
Description
BackgroundThe protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.
咨询热线:
客服:400-669-8850 产品:177-3110-0244 服务:136-8125-6816
在线客服:
产品咨询-1点击这里给我发消息QQ交谈
服务咨询-2点击这里给我发消息QQ交谈
微信二维码:
公司官网: biotyscience.com