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Cat No | BIOS-2521M |
Conjugate | |
Type | 单克隆抗体 |
Clone | E81 |
Source | Mouse |
Tag | N/A |
Size | 1 mg |
Application | WB; IF; IHC; ELISA; IP |
Format | Liquid |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in PBS. |
Storage | Store at –20 degree. Avoid repeated freeze/thaw cycles. |
Synonyms | Cofilin (E-8);Cofilin;CFL;丝切蛋白 |
Purification | |
MolecularWeight | 19-21 kDa |
Description | |
Background | Cofilin is ubiquitously expressed in eukaryotic cells where it binds to Actin, thereby regulating the rapid cycling of Actin assembly and disassembly essential for cellular viability. Cofilin is a low molecular weight protein that binds to filamentous (F) Actin by bridging two longitudinally associated Actin subunits changing the F-Actin filament twist. This process is allowed by the dephosphorylation of Cofilin Ser-3 by factors such as opsonized zymosan. Lim kinase 1, a serine kinase, phosphorylates Cofilin and renders it unable to bind and depolymerise F-Actin. |