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Mouse Anti-Cofilin (E-8) Monoclonal Antibody, clone E81

Cat NoBIOS-2521M
Conjugate
Type单克隆抗体
CloneE81
SourceMouse
TagN/A
Size1 mg
ApplicationWB; IF; IHC; ELISA; IP
FormatLiquid
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS.
StorageStore at –20 degree. Avoid repeated freeze/thaw cycles.
SynonymsCofilin (E-8);Cofilin;CFL;丝切蛋白
Purification
MolecularWeight19-21 kDa
Description
BackgroundCofilin is ubiquitously expressed in eukaryotic cells where it binds to Actin, thereby regulating the rapid cycling of Actin assembly and disassembly essential for cellular viability. Cofilin is a low molecular weight protein that binds to filamentous (F) Actin by bridging two longitudinally associated Actin subunits changing the F-Actin filament twist. This process is allowed by the dephosphorylation of Cofilin Ser-3 by factors such as opsonized zymosan. Lim kinase 1, a serine kinase, phosphorylates Cofilin and renders it unable to bind and depolymerise F-Actin.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.
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