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Cat No | BMM-049 |
Conjugate | |
Type | 抗体对 |
Clone | T31 |
Source | Mouse |
Size | 1mg |
Application | LF; ELISA |
Format | Liquid |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in PBS with 6% Mannitol, pH7.4. |
Storage | Store at -20 degree for long time. Avoid repeated freeze/thaw cycles. |
Synonyms | 35 kDa lectin;CBP35;GAL3;GALBP;Galectin-3;GALIG;L-31;Lectin L-29;LGALS2;LGALS3;MAC2 |
Purification | Protein A |
MolecularWeight | |
Description | |
Background | Galectins are a family of animal lectins defined by shared characteristic amino-acid sequences and affinity for β-galactose-containing oligosac-charides. Galectin-3, a 31-kDa member of the β-galactoside-binding proteins, contains one carbohydrate recognition domain (CRD) and a proline- and glycine-rich N-terminal domain through which is able to form oligomers. Galectin-3 is widely expressed in many normal tissues and a variety of tumors. It is found intracellularly in nucleus and cytoplasm or secreted outside of cell, being present on the cell surface or in the extracellular space. Galectin-3 is involved in various biological processes including cell growth, adhesion, differentiation, apoptosis, angiogenesis, immune response, neoplastic transformation and metastasis. Elevated serum galectin-3 levels have been reported in patients with breast, gastrointestinal, lung, or ovarian cancer, melanoma, and non-Hodgkin's lymphoma. |