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Mouse Anti-Thrombomodulin Monoclonal Antibody, Clone T88, det

Cat NoBIOS-2146-D
Conjugate
Type抗体对
CloneT88
SourceMouse
Size1 mg
ApplicationImmunology
ApplicationNoteRecommended Antibody pairs:BIOS-2146-C- BIOS-2146-D
FormatLiquid
Purity>90%
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS; pH 7.4.
StorageStore at -80 degree for long term.
SynonymsThrombomodulin;THBD;TM;Fetomodulin;CD141;THRM
PurificationSDS-PAGE
MolecularWeight
Description
BackgroundThrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Human Thrombomodulin/THBD predicts a signal peptide and a mature chain that consists of following domains: C-type lectin, EGF-like, transmembrane and cytoplasmic. Predominantly synthesized by vascular endothelial cells, THBD inhibits coagulation and fibrinolysis. THBD gene polymorphisims are associated with human disease and THBD plays a role in thrombosis, stroke, arteriosclerosis, and cancer. For example, increased serum levels of THBD, due to protease cleavage, have been associated with smoking, cardiac surgery, atherosclerosis, liver cirrhosis, diabetes mellitus, cerebral and myocardial infarction, and multiple sclerosis.
We can provide a variety of products such as diagnostic proteins; target proteins; cytokines; etc.
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