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Mouse Anti-Human GDF15 Monoclonal Antibody, Det

Cat NoBIOMY104-D
Conjugate
Type抗体对
SourceMouse
TagN/A
Size50 ul
ApplicationELISA Recommended Antibody pairs: BIOMY104-C?- BIOMY104-D?
FormatLiquid
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS
StorageStore at –20 degree. Avoid repeated freeze/thaw cycles.
Synonymsgrowth differentiation factor 15;GDF-15;MIC-1;MIC1;NAG-1;PDF;PLAB;PTGFB
PurificationProtein A
MolecularWeight
DescriptionThis product is a recombinant monoclonal antibody expressed from HEK293 cells.
BackgroundGrowth-differentiation factor 15 (GDF15), also known as MIC-1, is a secreted member of the transforming growth factor (TGF)-β superfamily, as a novel antihypertrophic regulatory factor in the heart. GDF-15 / GDF15 is not expressed in the normal adult heart but is induced in response to conditions that promote hypertrophy and dilated cardiomyopathy and it is expressed highly in liver. GDF-15 / GDF15 has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF-15 / GDF15 is synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein. GDF-15 / GDF15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression.

We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.

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